Farchi G, Fidanza F, Mariotti S, Menotti A
Laboratorio de Epidemiologia e Biostatistica, Istituto Superiore di Sanità, Rome, Italy.
Int J Epidemiol. 1992 Feb;21(1):74-81. doi: 10.1093/ije/21.1.74.
The relation of alcohol consumption to mortality is examined using the data of the Italian rural cohorts of the Seven Countries Study, a prospective investigation of factors related to cardiovascular disease (CVD). The present analysis includes 1536 men aged 45-64, whose dietary habits and food consumption, including alcoholic beverages, were measured in 1965. Of them, 463 men died in a follow-up period of 15 years. The analysis shows a J-shaped relationship between alcohol consumption, expressed as percentage of total daily energy intake, and both overall mortality and cardiovascular mortality; this J-shaped relationship is evident even after adjusting for age, cigarette smoking and occupation. The inverse relationship for consumption of small quantities of alcohol, which is represented by the left side of the J-curve, is no longer significant when all men with previous cardiovascular manifestations are excluded from the analysis, yet it is never completely eliminated.
利用七国研究中意大利农村队列的数据，对酒精摄入量与死亡率之间的关系进行了研究，该研究是一项关于心血管疾病（CVD）相关因素的前瞻性调查。本分析纳入了1536名年龄在45 - 64岁的男性，他们的饮食习惯和食物摄入量（包括酒精饮料）于1965年进行了测量。在这些人中，有463名男性在15年的随访期内死亡。分析表明，以每日总能量摄入百分比表示的酒精摄入量与总死亡率和心血管死亡率之间呈J形关系；即使在对年龄、吸烟和职业进行调整后，这种J形关系仍然明显。J曲线左侧所代表的少量饮酒的反比关系，在将所有既往有心血管表现的男性排除在分析之外时不再显著，但它从未完全消除。
