Capon Francesca, Trembath Richard C, Barker Jonathan N
Division of Medical Genetics, Department of Genetics and Cardiovascular Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK.
Dermatol Clin. 2004 Oct;22(4):339-47, vii. doi: 10.1016/S0733-8635(03)00125-6.
Psoriasis is a complex inflammatory disorder whose pathogenesis is likely to require the contribution of several genes and environmental triggers. Despite the difficulties posed by the study of multifactorial conditions, significant progress has been achieved in relation to the molecular genetic basis of psoriasis. It has long been recognized that the major histocompatibility complex (MHC) region on chromosome 6p21 harbors the main determinant conferring psoriasis susceptibility. The identification of non-MHC susceptibility regions across the genome has been hindered by the likely occurrence of genetic heterogeneity. Nonetheless, evidence for the assignment of a number of non-MHC loci has been achieved through studies, including the collaborative analysis of large patient cohorts, and also through the observation of overlap between psoriasis and atopic dermatitis susceptibility regions.
银屑病是一种复杂的炎症性疾病，其发病机制可能需要多个基因和环境触发因素的共同作用。尽管研究多因素疾病存在困难，但在银屑病的分子遗传学基础方面已取得了重大进展。长期以来，人们已经认识到位于6号染色体p21区域的主要组织相容性复合体（MHC）区域包含赋予银屑病易感性的主要决定因素。全基因组中非MHC易感区域的鉴定因可能存在的遗传异质性而受阻。尽管如此，通过包括对大量患者队列进行合作分析在内的研究，以及通过观察银屑病和特应性皮炎易感区域之间的重叠，已获得了一些非MHC基因座定位的证据。
