Department of Pharmacology, College of Korean Medicine, Sangji University, Wonju-si, Gangwon-do 26339, Republic of Korea.
Department of Korean Medicine Ophthalmology & Otolaryngology & Dermatology, College of Korean Medicine, Sangji University, Wonju-si, Gangwon-do 26339, Republic of Korea.
Mediators Inflamm. 2019 Mar 17;2019:3760934. doi: 10.1155/2019/3760934. eCollection 2019.
(SF) is a green alga rich in chlorophyll with unique flavor and taste. It is also called Maesaengi which has antioxidant and other physiological activities. In the present study, we evaluated the therapeutic effects of SF in a mouse model of body-induced atopic dermatitis (AD) and in tumor necrosis factor- and interferon--stimulated HaCaT keratinocytes. SF treatment (200 mg/mouse) inhibited the development of AD symptoms, compared to that in the control group, as evidenced from the improved dorsal skin lesion, reduced thickness and infiltration of inflammatory cells and smaller lymph nodes, and reduced levels of proinflammatory cytokines. In HaCaT keratinocytes, SF (10, 25, and 50 g/mL) suppressed the production of proinflammatory cytokines in a dose-dependent manner. In addition, SF reduced the phosphorylation of signal transducer and activator of transcription 1, which is one of the major signaling molecules involved in cellular inflammation. These results suggested that SF could be a potential therapeutic alternative for the treatment of AD.
(SF) 是一种富含叶绿素的绿藻，具有独特的风味和口感。它也被称为 Maesaengi，具有抗氧化和其他生理活性。在本研究中，我们评估了 SF 在小鼠特应性皮炎 (AD) 模型和肿瘤坏死因子-α 和干扰素-γ 刺激的 HaCaT 角质形成细胞中的治疗效果。与对照组相比，SF 治疗（200mg/只小鼠）抑制了 AD 症状的发展，表现在背部皮肤损伤得到改善、厚度和炎症细胞浸润减少以及淋巴结缩小，以及促炎细胞因子水平降低。在 HaCaT 角质形成细胞中，SF（10、25 和 50μg/mL）以剂量依赖性方式抑制促炎细胞因子的产生。此外，SF 减少了信号转导和转录激活因子 1 的磷酸化，这是参与细胞炎症的主要信号分子之一。这些结果表明 SF 可能是治疗 AD 的一种有潜力的治疗选择。
