Sullivan Amy E, Silver Robert M, LaCoursiere D Yvette, Porter T Flint, Branch D Ware
Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, 50 North Medical Drive, Salt Lake City, Utah 94132, USA.
Obstet Gynecol. 2004 Oct;104(4):784-8. doi: 10.1097/01.AOG.0000137832.86727.e2.
Some investigators have found a high frequency of abortus aneuploidy in women with recurrent miscarriage, suggesting the possibility of recurrent aneuploidy as a cause of recurrent miscarriage. Others contend that aneuploidy is not a cause of recurrent miscarriage. The purpose of this study was to investigate the relationship between fetal aneuploidy and recurrent miscarriage by estimating whether fetal aneuploidy is more common in patients with recurrent miscarriage than in patients with sporadic miscarriage
Recurrent miscarriage cases (n = 135) included women who had a subsequent miscarriage in which an abortus karyotype was obtained. Controls (n = 150) were patients experiencing a sporadic miscarriage who had fetal karyotypes performed as part of a study to assess the utility of abortus tissue for transplantation. Karyotype analysis was performed using standard G-banding techniques.
Abortuses from 122 cases and 133 controls were successfully karyotyped. Thirty-one (25.4%) abortuses from cases and 56 (42.1%) from controls were aneuploid (odds ratio 0.47, 95% confidence interval 0.27-0.80). Aneuploid abortuses occurred in 20% of cases and 25% of controls, aged 20-29 years, 19% of cases and 24% of controls, aged 30-34 years, 35% of cases and 47% of controls, aged 35-39 years, and 50% of both cases and controls, aged 40 years or older (not significant). Of 30 cases in whom 2 or more miscarriages were karyotyped, 3 (10%) had aneuploidy in each abortus.
In our population of recurrent miscarriage patients, abortus aneuploidy occurred significantly less often than in sporadic miscarriages. The rate of aneuploidy in this study was considerably lower than reported in other studies. If recurrent aneuploidy contributes to recurrent miscarriage, it does so in only a small number of patients.
II-2
一些研究者发现复发性流产女性中流产胎儿非整倍体的频率较高，提示复发性非整倍体可能是复发性流产的一个原因。另一些人则认为非整倍体不是复发性流产的原因。本研究的目的是通过评估胎儿非整倍体在复发性流产患者中是否比偶发性流产患者更常见，来探讨胎儿非整倍体与复发性流产之间的关系。
复发性流产病例（n = 135）包括那些随后发生流产且获得流产胎儿核型的女性。对照组（n = 150）是偶发性流产患者，她们进行胎儿核型分析是作为一项评估流产组织用于移植效用的研究的一部分。使用标准G显带技术进行核型分析。
122例病例和133例对照的流产胎儿成功进行了核型分析。病例组中有31例（25.
