Konopacka Maria
Zakład Radiobiologii Doświadczalnej i Klinicznej, Centrum Onkologii Oddział Gliwice, Instytut im. M. Skłodowskiej-w Gliwicach.
Postepy Hig Med Dosw (Online). 2004;58:343-8.
Vitamin C (ascorbic acid) has considerable antioxidant activity: it scavenges reactive oxygen species and may, thereby, prevent oxidative damage to important biological macromolecules, such as DNA, proteins, and lipids. Data concerning the influence of vitamin C on oxidative DNA damage are conflicting and some of the discrepancies can be explained by the different experimental methodologies employed. Data using biomarkers of oxidative damage of DNA bases in human lymphocytes in vitro have provided no compelling evidence to conclude that vitamin C supplementation can decrease the level of oxidative DNA damage. There are also no conclusive data from studies of strand breaks for a protective effect of ascorbic acid. The consumption of food rich in vitamin C (fruits and vegetables) appears more protective because it exerts more positive effects in decreasing oxidative DNA damage to human cells. Recent studies indicate that vitamin C is much more than just an antioxidant; it regulates the expression of some genes participating in apoptosis or DNA repair processes. The purpose of this review is to provide a summary of the role of vitamin C in oxidative DNA damage.
维生素C（抗坏血酸）具有相当强的抗氧化活性：它能清除活性氧，从而可能防止对重要生物大分子（如DNA、蛋白质和脂质）的氧化损伤。关于维生素C对氧化性DNA损伤影响的数据相互矛盾，其中一些差异可以用所采用的不同实验方法来解释。体外使用人类淋巴细胞中DNA碱基氧化损伤生物标志物的数据，没有提供确凿证据表明补充维生素C可降低氧化性DNA损伤水平。关于链断裂研究中也没有确凿数据表明抗坏血酸具有保护作用。食用富含维生素C的食物（水果和蔬菜）似乎更具保护作用，因为它在减少对人类细胞的氧化性DNA损伤方面发挥了更积极的作用。最近的研究表明，维生素C不仅仅是一种抗氧化剂；它还调节参与细胞凋亡或DNA修复过程的一些基因的表达。本综述的目的是总结维生素C在氧化性DNA损伤中的作用。
