Gebauer Fátima, Hentze Matthias W
Centre de Regulació Genómica, Passeig Marítim 37-49, 08003-Barcelona, Spain.
Nat Rev Mol Cell Biol. 2004 Oct;5(10):827-35. doi: 10.1038/nrm1488.
Translational control is widely used to regulate gene expression. This mode of regulation is especially relevant in situations where transcription is silent or when local control over protein accumulation is required. Although many examples of translational regulation have been described, only a few are beginning to be mechanistically understood. Instead of providing a comprehensive account of the examples that are known at present, we discuss instructive cases that serve as paradigms for different modes of translational control.
翻译控制被广泛用于调节基因表达。这种调节模式在转录沉默或需要对蛋白质积累进行局部控制的情况下尤为重要。尽管已经描述了许多翻译调节的例子,但只有少数开始从机制上得到理解。我们不是全面介绍目前已知的例子,而是讨论作为不同翻译控制模式范例的指导性案例。