通过 3'-非翻译区结合蛋白对 mRNAs 的翻译调控。
Translational control of mRNAs by 3'-Untranslated region binding proteins.
机构信息
Department of Molecular Biology, Yokohama City University School of Medicine, Yokohama 236-0004, Japan.
Laboratory of Infection and Prevention, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
出版信息
BMB Rep. 2017 Apr;50(4):194-200. doi: 10.5483/bmbrep.2017.50.4.040.
Eukaryotic gene expression is precisely regulated at all points between transcription and translation. In this review, we focus on translational control mediated by the 3'-untranslated regions (UTRs) of mRNAs. mRNA 3'-UTRs contain cis-acting elements that function in the regulation of protein translation or mRNA decay. Each RNA binding protein that binds to these cis-acting elements regulates mRNA translation via various mechanisms targeting the mRNA cap structure, the eukaryotic initiation factor 4E (eIF4E)-eIF4G complex, ribosomes, and the poly (A) tail. We also discuss translation-mediated regulation of mRNA fate. [BMB Reports 2017; 50(4): 194-200].
真核基因表达在转录和翻译之间的各个环节都受到精确调控。在这篇综述中，我们重点关注 mRNA 的 3'非翻译区（UTR）介导的翻译调控。mRNA 3'UTR 含有顺式作用元件，可在蛋白质翻译或 mRNA 降解的调节中发挥作用。与这些顺式作用元件结合的每个 RNA 结合蛋白通过靶向 mRNA 帽结构、真核起始因子 4E（eIF4E）-eIF4G 复合物、核糖体和多聚（A）尾的各种机制来调节 mRNA 翻译。我们还讨论了翻译介导的 mRNA 命运调节。[BMB 报告 2017;50(4):194-200]。
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