Smutek Daniel, Sucharda Petr, Sára Radim
3rd Department of Medicine, 1st Medical Faculty, Charles University Prague, Czech Republic.
Stud Health Technol Inform. 2002;90:8-12.
Sonography is a widely used non-invasive diagnostic tool and its main advantage is low cost in comparison with other diagnostic methods such as immunological analyses. In this work it is presented the relation between a sonographic image of thyroid gland and an immunological status of the patients with Hashimoto's lymphocytic thyroiditis (chronic inflammation of the thyroid gland). The results, evaluated on a set of 740 B-mode sonographic images from 37 subjects, show that raw values of individual image pixels in sonogram of thyroid gland with presence and without presence of anti-thyroid antibodies are significantly different (means 31.87 and 44.56; standard deviations 8.6 and 11.82; t = 3.4; p = 0.0017) and that they can be used for the prediction of presence of anti-thyreoglobulin and anti-thyreoperoxidasis antibodies. This result suggests the possibility to use this method in clinical diagnostic process for reducing the costs. Also the correlation between the image features and the level of antibodies was examined. The highest correlation was found for inverse difference moment and the level of anti-thyreoperoxidasis (coefficient of determination 0.43).
超声检查是一种广泛使用的非侵入性诊断工具，与免疫分析等其他诊断方法相比，其主要优点是成本低。在这项工作中，展示了甲状腺超声图像与桥本氏淋巴细胞性甲状腺炎（甲状腺慢性炎症）患者免疫状态之间的关系。对来自37名受试者的740幅B型超声图像进行评估的结果表明，存在和不存在抗甲状腺抗体的甲状腺超声图中单个图像像素的原始值存在显著差异（均值分别为31.87和44.56；标准差分别为8.6和11.82；t = 3.4；p = 0.0017），并且这些值可用于预测抗甲状腺球蛋白和抗甲状腺过氧化物酶抗体的存在。这一结果表明在临床诊断过程中使用该方法以降低成本的可能性。此外，还研究了图像特征与抗体水平之间的相关性。发现逆差矩与抗甲状腺过氧化物酶水平之间的相关性最高（决定系数为0.43）。
