Paperwalla Khatija N, Levin Tomer T, Weiner Joseph, Saravay Stephen M
Department of Psychiatry, Zucker Hillside Hospital, 75-59 23rd Street, Glen Oaks, NY 11004, USA.
Med Clin North Am. 2004 Nov;88(6):1483-94, x-xi. doi: 10.1016/j.mcna.2004.06.007.
The relationship between smoking and depression is bidirectional. Recent research has focused on nicotine's neurobiologic impact on the brain as it relates to depression. Genetic factors are also important and may account for up to 67% of smoking initiation, maintenance, and dependence. Because nicotine withdrawal may mimic and induce depression, appropriate clinical evaluation and treatment are essential to reduce the high morbidity and mortality associated with smoking and depression and maximize smoking cessation rates.
吸烟与抑郁症之间的关系是双向的。近期研究聚焦于尼古丁对大脑的神经生物学影响及其与抑郁症的关联。遗传因素也很重要，可能在高达67%的吸烟起始、维持及成瘾过程中起作用。由于尼古丁戒断可能模拟并诱发抑郁症，恰当的临床评估和治疗对于降低与吸烟和抑郁症相关的高发病率及死亡率、最大化戒烟成功率至关重要。
