Wozney John M, Seeherman Howard J
Wyeth Research, 87 CambridgePark Drive, Cambridge, Massachusetts 02140, USA.
Curr Opin Biotechnol. 2004 Oct;15(5):392-8. doi: 10.1016/j.copbio.2004.08.001.
Bioactive proteins signal host or transplanted cells to form the desired tissue type. Matrix systems are utilized to locally deliver the proteins and to maintain effective protein concentrations. For some indications, a matrix is required to define the physical form of the regenerated tissue. Substantial progress has been made in bone tissue engineering in recent years, based on the results of controlled clinical studies using bone morphogenetic proteins. Ongoing research in this area centers on the design of additional delivery matrices to expand the clinical indications, using synthetic delivery systems that mimic biological qualities of the natural materials currently in use. Although a similar rationale exists for the regeneration of articular cartilage with bioactive factors, advancement in this area has not been as substantial.
生物活性蛋白向宿主细胞或移植细胞发出信号，以形成所需的组织类型。利用基质系统来局部递送这些蛋白并维持有效的蛋白浓度。对于某些适应症，需要一种基质来确定再生组织的物理形态。近年来，基于使用骨形态发生蛋白的对照临床研究结果，骨组织工程取得了重大进展。该领域正在进行的研究集中在设计额外的递送基质以扩大临床适应症，采用模仿目前所用天然材料生物学特性的合成递送系统。尽管利用生物活性因子再生关节软骨也有类似的基本原理，但该领域的进展并不那么显著。
