Murray Elisabeth A, Wise Steven P
Laboratory of Neuropsychology, National Institute of Mental Health, Building 49, Room 1B80, MSC 4415, 49 Convent Drive, Bethesda, MD 20892-4415, USA.
Neurobiol Learn Mem. 2004 Nov;82(3):178-98. doi: 10.1016/j.nlm.2004.05.005.
Should the medial temporal lobe (MTL) of primates--which includes allocortical structures such as the hippocampus, neocortical structures such as the parahippocampal cortex, and nuclear structures such as the basolateral amygdala--be considered a single "thing"? According to the prevailing view, here termed the reification theory, the answer is yes. According to this theory, the MTL functions as an amalgamated entity that provides the neuronal mechanisms for declarative memory; the greater the damage to the MTL or any of its components, the greater the deleterious effects on declarative memory. A countervailing view, here called the balkanization theory, holds that the various components of the MTL process and store different kinds of information. According to this theory, damage to each part of the MTL causes a unique set of behavioral deficits-some involving memory, others involving perception, and yet others involving response selection. The empirical neuropsychological evidence favors the balkanization theory, as do some new concepts in theoretical neuroanatomy.
灵长类动物的内侧颞叶(MTL)——包括海马体等异皮质结构、海马旁回皮质等新皮质结构以及基底外侧杏仁核等核结构——应被视为一个单一的“事物”吗?根据目前流行的观点(这里称为实体化理论),答案是肯定的。根据这一理论,MTL作为一个融合的实体发挥作用,为陈述性记忆提供神经元机制;MTL或其任何组成部分受损越严重,对陈述性记忆的有害影响就越大。一种相反的观点(这里称为分裂理论)认为,MTL的各个组成部分处理和存储不同类型的信息。根据这一理论,MTL各部分的损伤会导致一系列独特的行为缺陷——有些涉及记忆,有些涉及感知,还有些涉及反应选择。神经心理学的实证证据支持分裂理论,理论神经解剖学中的一些新概念也支持这一理论。