Suzuki Wendy A
New York University, 4 Washington Place, New York, NY 10003, USA.
Neuron. 2009 Mar 12;61(5):657-66. doi: 10.1016/j.neuron.2009.02.008.
A dominant view in the learning and memory literature states that a subset of anatomically related structures within the medial temporal lobe (MTL), including the hippocampus, entorhinal, perirhinal, and parahippocampal cortices, forms a functionally related system specialized for declarative memory but not for perception. However, recent reports challenge this view, suggesting instead that the medial temporal lobe is not only important for memory, but also critical for certain forms of perception. In this review, I argue that little or no conclusive evidence currently exists to support the latter view. Experimental studies that have examined the perceptual functions of the MTL in monkeys are inconclusive because they fail to isolate perceptual from mnemonic task demands. Evaluation of conflicting results from studies in human amnesic patients suggests that extraneous damage to extra-MTL areas may underlie the reported perceptual deficits in the group of amnesic patients at the heart of this debate. See the related Review from Baxter, "Involvement of Medial Temporal Lobe Structures in Memory and Perception," in this issue of Neuron.
学习与记忆领域文献中的一种主流观点认为，内侧颞叶（MTL）内一组解剖学上相关的结构，包括海马体、内嗅皮质、嗅周皮质和海马旁皮质，形成了一个功能相关的系统，专门用于陈述性记忆而非感知。然而，最近的报告对这一观点提出了挑战，表明内侧颞叶不仅对记忆很重要，而且对某些形式的感知也至关重要。在这篇综述中，我认为目前几乎没有确凿的证据支持后一种观点。研究猴子MTL感知功能的实验研究尚无定论，因为它们未能将感知任务需求与记忆任务需求区分开来。对人类失忆症患者研究中相互矛盾结果的评估表明，MTL以外区域的额外损伤可能是这场争论核心的失忆症患者群体中所报告的感知缺陷的潜在原因。见本期《神经元》杂志中巴克斯特的相关综述《内侧颞叶结构在记忆和感知中的作用》。
