Politis I, Zhao X, McBride B W, Burton J H
Department of Animal and Poultry Science, University of Guelph, Ont., Canada.
Vet Immunol Immunopathol. 1992 Jan 31;30(4):399-410. doi: 10.1016/0165-2427(92)90108-3.
The ability of mammary macrophages treated with Staphylococcus aureus to induce antigen-specific T-cell proliferation was compared to that of the autologous blood monocytes. Induction of T-cell proliferation has been correlated with changes in major histocompatibility complex (MHC) class II antigen expression and interleukin 1 (IL-1) production by mammary macrophages and blood monocytes. The present study showed that both monocytes and mammary macrophages treated with S. aureus induced T-cell proliferation. However, there was a 3-fold decrease (P less than 0.05) in T-cell proliferation in macrophage cultures compared to those of blood monocytes, when these cells were treated with S. aureus. Mammary macrophages, the cells less effective in stimulating T-cell proliferation, expressed lower levels (2-fold) of MHC class II molecules and produced less IL-1 (3-fold) than blood monocytes. These data suggest that S. aureus may affect macrophage-T cell interaction by modulating the expression of MHC class II molecules and the synthesis of IL-1 by macrophages.
将用金黄色葡萄球菌处理过的乳腺巨噬细胞诱导抗原特异性T细胞增殖的能力与自体血单核细胞的这种能力进行了比较。T细胞增殖的诱导与乳腺巨噬细胞和血单核细胞主要组织相容性复合体（MHC）II类抗原表达及白细胞介素1（IL-1）产生的变化相关。本研究表明，用金黄色葡萄球菌处理过的单核细胞和乳腺巨噬细胞均可诱导T细胞增殖。然而，当这些细胞用金黄色葡萄球菌处理时，与血单核细胞相比，巨噬细胞培养物中T细胞增殖下降了3倍（P<0.05）。在刺激T细胞增殖方面效果较差的乳腺巨噬细胞，其MHC II类分子表达水平较低（2倍），产生的IL-1也比血单核细胞少（3倍）。这些数据表明，金黄色葡萄球菌可能通过调节巨噬细胞MHC II类分子的表达和IL-1的合成来影响巨噬细胞与T细胞的相互作用。
