Mariani-Kurkdjian P, Doit C, Deforche D, Brahimi N, Francois M, Van den Abbeele T, Bingen E
Service de microbiologie, hôpital Robert-Debré, Paris, France.
Pathol Biol (Paris). 2004 Oct;52(8):489-92. doi: 10.1016/j.patbio.2004.07.032.
A total of 206 recent throat isolates of Streptococcus pyogenes collected between 2002 and 2004 from children were tested for their susceptibility to penicillin, amoxycillin, erythromycin, clarythromycin and clindamycin. The erythromycin resistant isolates were further studied for their genetic mechanism of resistance by means of PCR. In all, 14.5% of the strains were erythromycin resistant and 13.5 and 1% expressed the constitutive MLS(B) and M resistance phenotypes and harbored the ermB and mef A genes respectively.
对2002年至2004年间从儿童中收集的206株化脓性链球菌近期咽喉分离株进行了青霉素、阿莫西林、红霉素、克拉霉素和克林霉素的药敏试验。对红霉素耐药分离株通过聚合酶链反应（PCR）进一步研究其耐药的遗传机制。总体而言，14.5%的菌株对红霉素耐药，13.5%和1%的菌株分别表现出组成型MLS（B）和M耐药表型，并分别携带ermB和mefA基因。
