Gonsu Hortense Kamga, Bomki Cynthia Mbimenyuy, Djomou François, Toukam Michel, Ndze Valantine Ngum, Lyonga Emilia Enjema, Mbakop Calixte Didier, Koulla-Shiro Sinata
Department of Microbiology, Haematology, Parasitology and Infectious diseases, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaounde, Cameroon; Bacteriological Laboratory, Yaoundé University Teaching Hospital, Yaoundé, Cameroun.
Department of Microbiology, Haematology, Parasitology and Infectious diseases, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaounde, Cameroon.
Pan Afr Med J. 2015 Feb 17;20:139. doi: 10.11604/pamj.2015.20.139.4810. eCollection 2015.
Sore throat is a common complaint in general practice which is more frequent in children. The most frequent pathogenic bacteria associated with this infection is Streptococcus pyogenes. Rapid Antigen Diagnostic Test (RADT) facilitates the rapid identification and consequently prompt treatment of patients, prevents complications, and also reduces the risk of spread of Group A Streptococcus (GAS). The main objective of this study was to assess the diagnostic value of a rapid streptococcal antigen detection test in patients with sore throat.
A cross-sectional descriptive study was carried out from January to April 2011 on patients aged 3 to 72 years consulting for pharyngitis or sore throat at the paediatric and Ear, Nose and Throat units of the University Teaching Hospital Yaounde and the Central Hospital Yaounde. Two throat swabs were collected per patient. One was used for the rapid test and the other for standard bacteriological analysis.
The prevalence of GAS in the study population was 22.5%. Out of the 71 samples collected, the RADT detected group A streptococcal antigens in 12 of 16 positive cultures giving a sensitivity of 75%. The specificity of the rapid test was 96%, with positive predictive value of 85.7%, and negative predictive value of 93% respectively.
Rapid test may have an additional value in the management of patients with high risk of having GAS infection. However, tests with a higher sensitivity are needed for accurate and reliable results for early diagnosis of patients with sore throat caused by GAS.
喉咙痛是普通门诊中常见的症状，在儿童中更为频繁。与这种感染相关的最常见致病细菌是化脓性链球菌。快速抗原诊断测试（RADT）有助于快速识别并因此及时治疗患者，预防并发症，还能降低A组链球菌（GAS）传播的风险。本研究的主要目的是评估快速链球菌抗原检测试验对喉咙痛患者的诊断价值。
2011年1月至4月，对雅温得大学教学医院儿科及耳鼻喉科以及雅温得中心医院中3至72岁因咽炎或喉咙痛前来就诊的患者进行了一项横断面描述性研究。每位患者采集两份咽拭子。一份用于快速检测，另一份用于标准细菌学分析。
研究人群中GAS的患病率为22.5%。在采集的71份样本中，RADT在16份阳性培养物中的12份中检测到A组链球菌抗原，灵敏度为75%。快速检测的特异性为96%，阳性预测值为85.7%，阴性预测值分别为93%。
快速检测在管理有GAS感染高风险的患者中可能具有附加价值。然而，需要灵敏度更高的检测才能获得准确可靠的结果，以便早期诊断由GAS引起的喉咙痛患者。
