Fowler Joanna S, Volkow Nora D, Kassed Cheryl A, Chang Linda
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA.
Sci Pract Perspect. 2007 Apr;3(2):4-16. doi: 10.1151/spp07324.
Modern imaging techniques enable researchers to observe drug actions and consequences as they occur and persist in the brains of abusing and addicted individuals. This article presents the five most commonly used techniques, explains how each produces images, and describes how researchers interpret them. The authors give examples of key findings illustrating how each technique has extended and deepened our knowledge of the neurobiological bases of drug abuse and addiction, and they address potential clinical and therapeutic applications.
现代成像技术使研究人员能够观察药物在滥用和成瘾个体大脑中的作用过程及其持续影响。本文介绍了五种最常用的技术，解释了每种技术如何生成图像，并描述了研究人员如何解读这些图像。作者给出了关键研究结果的示例，以说明每种技术如何拓展和深化了我们对药物滥用和成瘾神经生物学基础的认识，并且探讨了其潜在的临床和治疗应用。
