Serrano-Dueñas Marcos, Martínez-Martín Pablo, Vaca-Baquero Verónica
Abnormal Movements Clinic, Neurology Department, Carlos Andrade Marín Hospital, Quito, Ecuador.
Parkinsonism Relat Disord. 2004 Oct;10(7):433-7. doi: 10.1016/j.parkreldis.2004.05.002.
To validate the Ecuadorian Spanish-language version of the Parkinson's Disease Quality of Life Questionnaire (PDQL-EV).
Cross-sectional study of patients with Parkinson's Disease attending a Movement Disorders Clinic. MEASURES APPLIED: Hoehn and Yahr (HY), Unified Parkinson's Disease Rating Scale (UPDRS-3.0), Schwab and England Scale (SES), Pfeiffer Questionnaire (SPMSQ), Hospital Anxiety and Depression Scale (HADS). PDQ-39 and PDQL-EV were applied, the latter after translation and back translation.
The study included 137 patients with an age range of 69.43 +/- 10.18 years (mean +/- SD), duration of illness 5.87 +/- 2.58 years, and HY 2.28 +/- 0.77. The PDQL-EV internal consistency (Cronbach's alpha) yielded: Parkinson's symptoms (PS) 0.85; systemic symptoms (SS) 0.69; social function (SF) 0.81; and emotional function (EF) 0.78. The correlation between measurements varied from 0.68 (PS-SS) to 0.46 (SS-EF), and total measurement correlation from 0.58 (EF) to 0.74 (PS) (altogether, p < 0.0001). The correlation of PDQL with clinical variables was: HY -0.62; UPDRS (subscales 1, 2 and 3) -0.55, -0.76, and -0.48, respectively; SES 0.65; SPMSQ -0.35; HADS-anxiety -0.55; HADS-depression -0.67; and PDQ-39 -0.91 (altogether p < 0.0001). PDQL-EV scores were significantly different (p < 0.0001) between moderate and advanced stages, for all domains except for EF (p = 0.006).
The PDQ-EV has satisfactory internal consistency, and converging and discriminating validity.
验证帕金森病生活质量问卷厄瓜多尔西班牙语版（PDQL-EV）。
对就诊于运动障碍门诊的帕金森病患者进行横断面研究。应用的测量方法：霍恩和雅尔分级（HY）、统一帕金森病评定量表（UPDRS-3.0）、施瓦布和英格兰量表（SES）、 Pfeiffer问卷（SPMSQ）、医院焦虑抑郁量表（HADS）。应用了PDQ-39和PDQL-EV，后者经过翻译和回译。
该研究纳入了137例患者，年龄范围为69.43±10.18岁（均值±标准差），病程5.87±2.58年，HY分级为2.28±0.77。PDQL-EV的内部一致性（克朗巴哈系数）结果如下：帕金森症状（PS）为0.85；全身症状（SS）为0.69；社会功能（SF）为0.81；情感功能（EF）为0.78。各测量指标之间的相关性从0.68（PS-SS）到0.46（SS-EF）不等，总体测量相关性从0.58（EF）到0.74（PS）（总体而言，p<0.0001）。PDQL与临床变量的相关性为：HY -0.62；UPDRS（第1、2和3分量表）分别为-0.55、-0.76和-0.48；SES 0.65；SPMSQ -0.35；HADS-焦虑 -0.55；HADS-抑郁 -0.67；以及PDQ-39 -0.91（总体p<0.0001）。除EF外（p = 0.006），所有领域在中度和晚期阶段的PDQL-EV评分均有显著差异（p<0.0001）。
PDQ-EV具有令人满意的内部一致性、聚合效度和区分效度。
