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21世纪第一个十年的代谢组学:构建通向个性化健康的道路。

Metabolomics in the opening decade of the 21st century: building the roads to individualized health.

作者信息

German J B, Bauman D E, Burrin D G, Failla M L, Freake H C, King J C, Klein S, Milner J A, Pelto G H, Rasmussen K M, Zeisel S H

机构信息

American Society for Nutritional Sciences Long Range Planning Committee, USA.

出版信息

J Nutr. 2004 Oct;134(10):2729-32. doi: 10.1093/jn/134.10.2729.

Abstract

It is rapidly becoming possible to measure hundreds or thousands of metabolites in small samples of biological fluids or tissues. This makes it possible to assess the metabolic component of nutritional phenotypes and will allow individualized dietary recommendations. ASNS has to take action to ensure that appropriate technologies are developed and that metabolic databases are constructed with the right inputs and organization. The relations between diet and metabolomic profiles and between those profiles and health and disease must be established. ASNS also should consider the social implications of these advances and plan for their appropriate utilization.

摘要

在生物体液或组织的小样本中快速测量数百种或数千种代谢物正变得越来越可行。这使得评估营养表型的代谢成分成为可能,并将实现个性化的饮食建议。美国营养学会(ASNS)必须采取行动,确保开发适当的技术,并确保利用正确的输入数据和组织方式构建代谢数据库。必须建立饮食与代谢组学图谱之间以及这些图谱与健康和疾病之间的关系。ASNS还应考虑这些进展的社会影响,并规划其适当的利用方式。

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