Yim Jang-Shim, Kim Young-Suk, Moon Sang-Kwan, Cho Ki-Ho, Bae Hyung-Sup, Kim Jung-Jin, Park Eun-Kyung, Kim Dong-Hyun
College of Oriental Medicine, Kyung Hee University, Dongdaemun-ku, Seoul, Korea.
Biol Pharm Bull. 2004 Oct;27(10):1580-3. doi: 10.1248/bpb.27.1580.
To evaluate the pharmacological actions of herbal medicines, metabolic activities of herbal medicine components, ginsenoside Rb1, glycyrrhizin, geniposide and baicalin to their bioactive compounds compound K, 18beta-glycyrrhetic acid, genipin and baicalein by fecal specimens were measured. Their metabolic activities were 646.1+/-591.4, 29.4+/-51.7, 926.3+/-569.6 and 3884.6+/-1400.1 micromol/h/g, respectively. The profiles of these metabolic activities of baicalin and ginsenoside Rb1 were not significantly different to those of water extracts of Scutellariae Radix and Ginseng Radix. None of the metabolic activities tested were different between males and females, or between ages. However, the difference in these metabolic activities in individuals was significant. These results suggest that the human intestinal microflora enzymes that convert herbal components to their bioactive compounds may be used as selection markers of responders to traditional medicines.
为评估草药的药理作用，通过粪便样本测定了草药成分人参皂苷Rb1、甘草酸、栀子苷和黄芩苷向其生物活性化合物化合物K、18β-甘草次酸、京尼平和黄芩素的代谢活性。它们的代谢活性分别为646.1±591.4、29.4±51.7、926.3±569.6和3884.6±1400.1微摩尔/小时/克。黄芩苷和人参皂苷Rb1的这些代谢活性谱与黄芩和人参水提取物的代谢活性谱无显著差异。所测试的代谢活性在男性和女性之间或不同年龄之间均无差异。然而，个体间这些代谢活性的差异是显著的。这些结果表明，将草药成分转化为其生物活性化合物的人体肠道微生物酶可作为传统药物反应者的选择标志物。
