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Watanabe heritable hyperlipidemic rabbits. Familial hypercholesterolemia.

作者信息

Atkinson J B, Swift L L, Virmani R

机构信息

Department of Pathology, Vanderbilt University, Nashville, Tennessee.

出版信息

Am J Pathol. 1992 Mar;140(3):749-53.

PMID:1546748
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1886168/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/126b/1886168/3435c9c83ddc/amjpathol00087-0218-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/126b/1886168/bfd15ca7d4a3/amjpathol00087-0217-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/126b/1886168/a4441f313557/amjpathol00087-0217-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/126b/1886168/79e60f0f84d6/amjpathol00087-0218-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/126b/1886168/3435c9c83ddc/amjpathol00087-0218-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/126b/1886168/bfd15ca7d4a3/amjpathol00087-0217-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/126b/1886168/a4441f313557/amjpathol00087-0217-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/126b/1886168/79e60f0f84d6/amjpathol00087-0218-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/126b/1886168/3435c9c83ddc/amjpathol00087-0218-b.jpg

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本文引用的文献

1
WHHL-rabbit: a low density lipoprotein receptor-deficient animal model for familial hypercholesterolemia.WHHL兔：一种用于家族性高胆固醇血症的低密度脂蛋白受体缺陷动物模型。
FEBS Lett. 1980 Aug 25;118(1):81-4. doi: 10.1016/0014-5793(80)81223-3.
2
Concentration and composition of lipoproteins in blood plasma of the WHHL rabbit. An animal model of human familial hypercholesterolemia.WHHL兔血浆中脂蛋白的浓度和组成。人类家族性高胆固醇血症的动物模型。
Arteriosclerosis. 1982 Nov-Dec;2(6):467-74. doi: 10.1161/01.atv.2.6.467.
3
Cellular pathology of progressive atherosclerosis in the WHHL rabbit. An animal model of familial hypercholesterolemia.
WHHL兔进行性动脉粥样硬化的细胞病理学。家族性高胆固醇血症的动物模型。
Arteriosclerosis. 1983 Jan-Feb;3(1):87-101. doi: 10.1161/01.atv.3.1.87.
4
Does nifedipine suppress atherogenesis in WHHL rabbits?
Atherosclerosis. 1984 Oct;53(1):91-8. doi: 10.1016/0021-9150(84)90109-6.
5
Defective lipoprotein receptors and atherosclerosis. Lessons from an animal counterpart of familial hypercholesterolemia.有缺陷的脂蛋白受体与动脉粥样硬化。家族性高胆固醇血症动物模型的启示。
N Engl J Med. 1983 Aug 4;309(5):288-96. doi: 10.1056/NEJM198308043090507.
6
Animal models in atherosclerosis research.动脉粥样硬化研究中的动物模型。
Exp Mol Pathol. 1985 Feb;42(1):1-28. doi: 10.1016/0014-4800(85)90015-2.
7
Fatty streak initiation in Watanabe Heritable Hyperlipemic and comparably hypercholesterolemic fat-fed rabbits.
Arteriosclerosis. 1987 Jan-Feb;7(1):9-23. doi: 10.1161/01.atv.7.1.9.
8
Ischemic heart disease in the WHHL rabbit: a model for myocardial injury in genetically hyperlipidemic animals.WHHL兔的缺血性心脏病：一种遗传性高脂血症动物心肌损伤的模型。
Am Heart J. 1987 Feb;113(2 Pt 1):280-8. doi: 10.1016/0002-8703(87)90266-3.
9
A receptor-mediated pathway for cholesterol homeostasis.胆固醇稳态的受体介导途径。
Science. 1986 Apr 4;232(4746):34-47. doi: 10.1126/science.3513311.
10
Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit.普罗布考的抗动脉粥样硬化作用与其降胆固醇作用无关：体内抗氧化剂可选择性抑制富含巨噬细胞的脂肪条纹中低密度脂蛋白降解并减缓渡边遗传性高脂血症兔动脉粥样硬化进展的证据。
Proc Natl Acad Sci U S A. 1987 Nov;84(21):7725-9. doi: 10.1073/pnas.84.21.7725.