Kouchi Mami, Ueda Yoshinaka, Horie Hiroshi, Tanaka Kohji
Toxicology Group, Safety Research Laboratories, Dainippon Pharmaceutical Co., Ltd, 33-94 Enokicho, Suita, Osaka, 564-0053, Japan.
Vet Ophthalmol. 2006 May-Jun;9(3):145-8. doi: 10.1111/j.1463-5224.2006.00453.x.
Hyperlipidemic ocular lesions are described for Watanabe heritable hyperlipidemic (WHHL) rabbits. Male WHHL rabbits 8 months old exhibited serum hyperlipidemia and ophthalmoscopically yellowish-white lesions along the corneoscleral junction and in the iris. Histopathologically, foamy macrophages aggregated in the stroma of the cornea, iris, and ciliary body were observed. These findings have been interpreted as lipid keratopathy. In addition, multiple clusters of a large number of foamy macrophages occurred throughout the choroid and sclera in association with the blood vessels. The lesions in the choroid and sclera could not be detected ophthalmoscopy, yet were much more prominent than those in the cornea, iris, and ciliary body, suggesting greater involvement and earlier onset of lipidosis at these sites associated with hyperlipidemia in WHHL rabbits.
渡边遗传性高脂血症（WHHL）兔存在高脂血症性眼部病变。8月龄雄性WHHL兔表现出血清高脂血症，眼底镜检查显示在角膜巩膜交界处和虹膜有黄白色病变。组织病理学检查发现，角膜、虹膜和睫状体基质中有泡沫状巨噬细胞聚集。这些发现被解释为脂质角膜病。此外，在脉络膜和巩膜中，与血管相关的部位出现了大量泡沫状巨噬细胞的多个聚集群。脉络膜和巩膜中的病变在眼底镜检查中无法检测到，但比角膜、虹膜和睫状体中的病变更为明显，这表明在WHHL兔中，这些与高脂血症相关的部位脂质沉积更严重且发病更早。
