Watanabe Y, Ito T, Shiomi M
Atherosclerosis. 1985 Jul;56(1):71-9. doi: 10.1016/0021-9150(85)90085-1.
To increase the incidence of coronary atherosclerosis in Watanabe heritable hyperlipidemic (WHHL) rabbits, an animal model for familial hypercholesterolemia, selective breeding has been carried out. The results obtained are as follows: The incidence of coronary atherosclerosis before selective breeding was 21.8%, whereas that after the breeding was 58.9% (average values for rabbits between 4 and 12 months old), showing that the incidence of coronary atherosclerosis can be increased by an appropriate breeding technique. With respect to the relationships between parents and offspring, if parents had coronary atherosclerosis, then the incidence of the disease in the offspring was 83.3%; therefore the disease was strongly heritable. The mean total cholesterol (TC) and triglyceride (TG) levels of the colony before selective breeding were 579 +/- 163 mg/dl and 471 +/- 144 mg/dl, respectively, while those after the breeding were 665 +/- 151 mg/dl and 603 +/- 178 mg/dl; serum lipid levels increased in parallel with incidence of coronary atherosclerosis. The earliest development of coronary atherosclerosis in the colony after selective breeding was found in 4-month-old rabbits and the whole colony suffered from the disease at 18 months of age.
为提高家族性高胆固醇血症动物模型——渡边遗传性高脂血症（WHHL）兔的冠状动脉粥样硬化发病率，已开展了选择性育种。获得的结果如下：选择性育种前冠状动脉粥样硬化的发病率为21.8%，而育种后的发病率为58.9%（4至12月龄兔的平均值），表明通过适当的育种技术可提高冠状动脉粥样硬化的发病率。关于亲子关系，如果父母患有冠状动脉粥样硬化，那么后代中该疾病的发病率为83.3%；因此该疾病具有很强的遗传性。选择性育种前群体的平均总胆固醇（TC）和甘油三酯（TG）水平分别为579±163mg/dl和471±144mg/dl，而育种后的水平分别为665±151mg/dl和603±178mg/dl；血脂水平与冠状动脉粥样硬化的发病率平行升高。选择性育种后群体中最早出现冠状动脉粥样硬化的是4月龄兔，整个群体在18月龄时均患有该疾病。
