Kaiser Lana G, Schuff Norbert, Cashdollar Nathan, Weiner Michael W
Department of Radiology, University of California-San Francisco, MR Unit VA Medical Center at San Francisco, San Francisco, California 94141, USA.
NMR Biomed. 2005 Feb;18(1):51-5. doi: 10.1002/nbm.927.
The scyllo-inositol and myo-inositol concentrations of 24 normal human subjects were measured in vivo using 1H magnetic resonance spectroscopy at 4 T. Single-voxel short-echo (TE = 15 ms) metabolite spectra were collected from the white matter region of the corona radiata. Test-retest studies performed on 10 normal subjects demonstrated coefficient of variation for scyllo-inositol measurement of 37%, compared with 6% for N-acetyl aspartate. Comparisons between old and young subjects showed higher concentration of scyllo-inositol and myo-inositol in older subjects and a trend for a correlation between scyllo-inositol and myo-inositol levels across subjects.
利用4T的1H磁共振波谱技术在体内测量了24名正常人类受试者的scyllo-肌醇和肌醇浓度。从放射冠的白质区域采集了单体素短回波（TE = 15 ms）代谢物谱。对10名正常受试者进行的重测研究表明，scyllo-肌醇测量的变异系数为37%，而N-乙酰天门冬氨酸为6%。老年和年轻受试者之间的比较显示，老年受试者中scyllo-肌醇和肌醇的浓度较高，并且在不同受试者中scyllo-肌醇和肌醇水平之间存在相关趋势。
