Seaquist E R, Gruetter R
Department of Medicine, University of Minnesota Medical School, Minneapolis, USA.
Magn Reson Med. 1998 Feb;39(2):313-6. doi: 10.1002/mrm.1910390220.
The peak at 3.35 ppm in the 1H-NMR spectrum characteristic for scyllo-inositol may be a marker for cerebral pathology, although it has a well-known constant concentration relative to myo-inositol. Such a peak was observed with an intensity at least 300% above normal in the brain of a healthy volunteer. The scyllo-inositol signal was assigned based on the detection of a corresponding peak at 74.5 ppm in the 13C-NMR spectrum and on the demonstration of singlet characteristics of the proton signal. The presence of substantial brain concentrations of scyllo-inositol suggests that scyllo-inositol metabolism may be regulated independently from myo-inositol and that such concentrations are compatible with normal health.
尽管相对于肌醇而言， scyllo-肌醇在1H-NMR谱中3.35 ppm处的峰具有已知的恒定浓度，但该峰可能是脑部病变的一个标志物。在一名健康志愿者的大脑中观察到这样一个峰，其强度比正常水平至少高出300%。scyllo-肌醇信号是基于在13C-NMR谱中74.5 ppm处相应峰的检测以及质子信号单峰特征的证明而确定的。大脑中存在大量的scyllo-肌醇表明，scyllo-肌醇的代谢可能独立于肌醇进行调节，并且这样的浓度与正常健康状况相符。
