Cristallini Caterina, Ciardelli Gianluca, Barbani Niccoletta, Giusti Paolo
C.N.R. Institute for Composite and Biomedical Materials, Via Diotisalvi 2, 56126 Pisa, Italy.
Macromol Biosci. 2004 Jan 21;4(1):31-8. doi: 10.1002/mabi.200300026.
The preparation of new polymeric membranes using molecular imprinting technology for application in blood filtration devices is described. Membranes, based on an acrylic acid-acrylonitrile copolymer, produced through phase inversion, were modified by introducing specific binding sites for uric acid into their structure. The materials prepared are intended for use to selectively remove uric acid from the blood in the case of increased serum uric acid values associated with different pathologies. The interactions at a molecular level between the membrane forming copolymer and the template were investigated by means of calorimetry, infrared spectroscopy and morphological analysis. The presence of interactions between the template and the copolymer, and a good thermal stability of the imprinted membranes were observed. In addition, the results of rebinding tests on the imprinted membranes indicated a good capacity of molecular recognition for the template and satisfactory selectivity properties towards compounds of similar structure such as theophylline. Membrane permeability values suggest their application as (ultra) haemofiltration devices. Poly(acrylonitrile-co-acrylic acid) membrane.
描述了使用分子印迹技术制备用于血液过滤装置的新型聚合物膜的方法。通过相转化制备的基于丙烯酸-丙烯腈共聚物的膜，通过在其结构中引入尿酸的特异性结合位点进行了改性。所制备的材料旨在用于在与不同病理相关的血清尿酸值升高的情况下从血液中选择性去除尿酸。通过量热法、红外光谱和形态分析研究了成膜共聚物与模板之间的分子水平相互作用。观察到模板与共聚物之间存在相互作用，且印迹膜具有良好的热稳定性。此外，对印迹膜的再结合测试结果表明其对模板具有良好的分子识别能力，对结构相似的化合物如茶碱具有令人满意的选择性。膜的渗透值表明它们可作为（超）血液滤过装置应用。聚（丙烯腈-共-丙烯酸）膜。
