Ruszymah B H I
Department of Physiology, Medical Faculty of Universiti Kebangsaan Malaysia.
Med J Malaysia. 2004 May;59 Suppl B:30-1.
Patient own fibrin may act as the safest, cheapest and immediate available biodegradable scaffold material in clinical 1 tissue engineering. This study investigated the feasibility of using patient own fibrin isolated from whole blood to construct a new human cartilage, skin and bone. Constructed in vitro tissues were implanted on the dorsal part of the nude mice for in vivo maturation. After 8 weeks of implantation, the engineered tissues were removed for histological analysis. Our results demonstrated autologous fibrin has great potential as clinical scaffold material to construct various human tissues.
患者自身的纤维蛋白可能是临床组织工程中最安全、最便宜且可即时获取的可生物降解支架材料。本研究调查了使用从全血中分离出的患者自身纤维蛋白构建新型人体软骨、皮肤和骨骼的可行性。在体外构建的组织被植入裸鼠背部以进行体内成熟。植入8周后，取出工程组织进行组织学分析。我们的结果表明，自体纤维蛋白作为构建各种人体组织的临床支架材料具有巨大潜力。
