Layer upon layer: thermoregulation in schizophrenia.

A review of the relevant published literature regarding disorders of thermoregulation in people with schizophrenia was undertaken. This entailed a search of the Medline and PsychINFO databases to 28th May 2003 using the search terms "schizophrenia and thermoregulation" and "schizophrenia and temperature". The relevant articles as well as secondary references were reviewed. It has generally been shown that, when compared with controls, people with schizophrenia exhibit dysregulation of body temperature including different baseline temperatures; abnormal daily range of temperatures and diurnal variation showing an earlier peak; an impaired ability to compensate to heat stress; and compensating more effectively to cold stress. This may be intrinsic to the syndrome of schizophrenia but is potentially confounded by the administration of neuroleptic medication. The underlying cause is likely to be a combination of "peripheral" and "central" mechanisms of thermoregulation. Further study is required to delineate clearly the quality and magnitude of the temperature dysregulation as well as elucidating its mechanism(s). This could further our understanding of the mechanism underlying the syndrome of schizophrenia.