三氟甲磺酸汞催化由1-炔-5-酮合成2-甲基呋喃
Mercuric triflate-catalyzed synthesis of 2-methylfurans from 1-alkyn-5-ones.
作者信息
Imagawa Hiroshi, Kurisaki Takahiro, Nishizawa Mugio
机构信息
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.
出版信息
Org Lett. 2004 Oct 14;6(21):3679-81. doi: 10.1021/ol048730p.
PMID:15469322
Abstract
[reaction: see text] 2-Methylfurans were prepared by an effective cyclization of 1-alkyn-5-ones in the presence of mercuric triflate as the catalyst under very mild reaction conditions with high catalytic turnover up to 100 times. Benzene, toluene, or dichloromethane was the solvent of choice.
摘要
[反应：见正文] 在三氟甲磺酸汞作为催化剂存在下，通过1-炔-5-酮的有效环化反应，在非常温和的反应条件下制备了2-甲基呋喃，催化周转率高达100倍。苯、甲苯或二氯甲烷是首选溶剂。
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