使用三氟甲磺酸镓(III)作为催化剂高效一锅法合成氟化苯并咪唑啉、苯并噻唑啉、苯并恶唑啉和二氢苯并恶嗪酮。
Efficient one-pot synthesis of fluorinated benzimidazolines, benzothiazolines, benzoxazolines, and dihydrobenzoxazinones using gallium(III) triflate as a catalyst.
作者信息
Prakash G K Surya, Mathew Thomas, Panja Chiradeep, Vaghoo Habiba, Venkataraman Karthik, Olah George A
机构信息
Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, Los Angeles, California 90089-1661, USA.
出版信息
Org Lett. 2007 Jan 18;9(2):179-82. doi: 10.1021/ol062562e.
One-pot synthesis of fluorinated benzimidazolines, benzothiazolines, benzoxazolines, and dihydrobenzoxazinones was easily achieved under mild conditions in high yields and purity through gallium(III) triflate mediated condensation-cyclization. Introduction of fluorine atoms favors the formation of the five-membered heterocycles over seven-membered heterocycles. [reaction: see text].
通过三氟甲磺酸镓介导的缩合环化反应，在温和条件下可轻松实现一锅法合成氟化苯并咪唑啉、苯并噻唑啉、苯并恶唑啉和二氢苯并恶嗪酮，产率高且纯度高。氟原子的引入相较于七元杂环更有利于五元杂环的形成。[反应：见正文]
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