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危重症患者体内的促红细胞生成素——其作用是否不止于血液方面?

Erythropoietin in the critically ill - is it more than just blood?

作者信息

Corwin Howard L

机构信息

Dartmouth Medical School, Lebanon, New Hampshire, USA.

出版信息

Crit Care. 2004 Oct;8(5):325-6. doi: 10.1186/cc2949. Epub 2004 Sep 6.

DOI:10.1186/cc2949
PMID:15469592
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1065033/
Abstract

Erythropoietin (EPO) has been in clinical use for the treatment of anemia for over 15 years. Recently it has been demonstrated that EPO has actions other than stimulating the bone marrow. It has been suggested that due to its tissue protecting effect, EPO may be effective in improving outcome in the critically ill.

摘要

促红细胞生成素(EPO)已在临床用于治疗贫血超过15年。最近有研究表明,EPO除了刺激骨髓外还有其他作用。有人提出,由于其组织保护作用,EPO可能对改善危重症患者的预后有效。

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本文引用的文献

1
Science review: recombinant human erythropoietin in critical illness: a role beyond anemia?科学综述:重组人促红细胞生成素在危重症中的作用:是否超越了贫血范畴?
Crit Care. 2004 Oct;8(5):337-41. doi: 10.1186/cc2897. Epub 2004 Jun 16.
2
Epoetin alfa. Clinical evolution of a pleiotropic cytokine.促红细胞生成素α。一种多效细胞因子的临床演变。
Arch Intern Med. 2004 Feb 9;164(3):262-76. doi: 10.1001/archinte.164.3.262.
3
Erythropoietin is a multifunctional tissue-protective cytokine.促红细胞生成素是一种多功能的组织保护细胞因子。
Curr Hematol Rep. 2003 Nov;2(6):465-70.
4
The problems and challenges of immunotherapy in sepsis.脓毒症免疫治疗的问题与挑战。
Chest. 2003 May;123(5 Suppl):451S-9S. doi: 10.1378/chest.123.5_suppl.451s.
5
The pathophysiology and treatment of sepsis.脓毒症的病理生理学与治疗
N Engl J Med. 2003 Jan 9;348(2):138-50. doi: 10.1056/NEJMra021333.
6
The immunopathogenesis of sepsis.脓毒症的免疫发病机制。
Nature. 2002;420(6917):885-91. doi: 10.1038/nature01326.
7
Efficacy of recombinant human erythropoietin in critically ill patients: a randomized controlled trial.重组人促红细胞生成素对危重症患者的疗效:一项随机对照试验。
JAMA. 2002 Dec 11;288(22):2827-35. doi: 10.1001/jama.288.22.2827.
8
Erythropoietin therapy for acute stroke is both safe and beneficial.促红细胞生成素治疗急性中风既安全又有益。
Mol Med. 2002 Aug;8(8):495-505.
9
Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury.促红细胞生成素可穿过血脑屏障,以预防实验性脑损伤。
Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10526-31. doi: 10.1073/pnas.97.19.10526.
10
The use of subcutaneous erythropoietin and intravenous iron for the treatment of the anemia of severe, resistant congestive heart failure improves cardiac and renal function and functional cardiac class, and markedly reduces hospitalizations.皮下注射促红细胞生成素和静脉注射铁剂用于治疗重度难治性充血性心力衰竭的贫血,可改善心脏和肾功能以及心功能分级,并显著减少住院次数。
J Am Coll Cardiol. 2000 Jun;35(7):1737-44. doi: 10.1016/s0735-1097(00)00613-6.