Menke Thomas, Niklowitz Petra, de Sousa Gideon, Reinehr Thomas, Andler Werner
Vestische Kinderklinik Datteln, Universität Witten/Herdecke, Dr.-Friedrich-Steiner-Str. 5, D-45711 Datteln, Germany.
Clin Chim Acta. 2004 Nov;349(1-2):121-7. doi: 10.1016/j.cccn.2004.06.015.
Childhood obesity is associated with lower plasma levels of lipophilic antioxidants which may contribute to a deficient protection of low-density lipoproteins (LDL). An increased plasma level of oxidized LDL in obese people with insulin resistance has been demonstrated. The lipophilic antioxidant coenzyme Q10 (CoQ10) is known as an effective inhibitor of oxidative damage in LDL as well. The aim of the present study was to compare the CoQ10 levels in obese and normal weight children.
The CoQ10 plasma concentrations were measured in 67 obese children (BMI>97th percentile) and related to their degree of insulin resistance. Homeostasis model assessment (HOMA) was used to detect the degree of insulin resistance. The results were compared to a control group of 50 normal weight and apparently healthy children. The results of the CoQ10 levels were related to the plasma cholesterol concentrations.
After adjustment to plasma cholesterol, no significant difference in the CoQ10 levels between obese and normal weight children could be demonstrated. Furthermore, there was no difference between insulin-resistant and non-insulin-resistant obese children.
CoQ10 plasma levels are not reduced in obese children and are not related to insulin resistance.
儿童肥胖与亲脂性抗氧化剂的血浆水平降低有关，这可能导致对低密度脂蛋白（LDL）的保护不足。已有研究表明，胰岛素抵抗的肥胖人群血浆氧化型LDL水平升高。亲脂性抗氧化剂辅酶Q10（CoQ10）同样也是LDL氧化损伤的有效抑制剂。本研究的目的是比较肥胖儿童和正常体重儿童的CoQ10水平。
测量了67名肥胖儿童（BMI>第97百分位数）的血浆CoQ10浓度，并将其与胰岛素抵抗程度相关联。采用稳态模型评估（HOMA）来检测胰岛素抵抗程度。将结果与50名正常体重且明显健康的儿童对照组进行比较。CoQ10水平的结果与血浆胆固醇浓度相关。
在调整血浆胆固醇后，未发现肥胖儿童和正常体重儿童的CoQ10水平存在显著差异。此外，胰岛素抵抗肥胖儿童和非胰岛素抵抗肥胖儿童之间也没有差异。
肥胖儿童的血浆CoQ10水平未降低，且与胰岛素抵抗无关。
