肥胖与非肥胖者体内维生素 A、E、辅酶 Q(10)与胰岛素抵抗程度的相关性。
Correlation between vitamin A, E, coenzyme Q(10) and degree of insulin resistance in obese and non-obese subjects.
机构信息
University of Selcuk, Meram Faculty of Medicine, Biyokimya AD, 42080, Department of Biochemistry, Konya, Turkey.
出版信息
J Clin Biochem Nutr. 2011 Nov;49(3):159-63. doi: 10.3164/jcbn.11-08. Epub 2011 Oct 5.
The aim of the present study was to investigate correlation between plasma vitamin A, vitamin E, serum coenzyme Q(10) levels and degree of insulin resistance in obese and normal weight people. The study was performed on 98 (21 Male, 77 Female) obese people and 78 (20 Male, 58 Female) control subjects. Vitamin A, E and coenzyme Q(10) levels were adjusted to the lipid levels. Adjusted vitamin A and E and coenzyme Q(10) levels of the obese female group were significantly lower than those of the control female group. Adjusted vitamin A and coenzyme Q(10) levels of the obese male group were significantly lower than those of the control male group. Insulin resistance level of the obese female and male groups were significantly higher than that of the control female and male groups. There were no significant correlations between serum coenzyme Q(10), plasma vitamin A and E levels and insulin resistance in obese and control subjects. Our findings show that it is essential to use the lipid adjusted levels of lipid soluble nutrients in obesity. Also, we have found no association between insulin resistance and vitamin A, vitamin E and coenzyme Q(10) levels in obese subjects.
本研究旨在探讨肥胖人群和正常体重人群血浆维生素 A、维生素 E、血清辅酶 Q(10)水平与胰岛素抵抗程度的相关性。研究对象为 98 名肥胖者（21 名男性，77 名女性）和 78 名对照者（20 名男性，58 名女性）。维生素 A、E 和辅酶 Q(10)水平根据血脂水平进行了调整。肥胖女性组的调整后维生素 A 和 E 以及辅酶 Q(10)水平明显低于对照组女性组。肥胖男性组的调整后维生素 A 和辅酶 Q(10)水平明显低于对照组男性组。肥胖女性和男性组的胰岛素抵抗水平明显高于对照组女性和男性组。肥胖人群和对照组人群的血清辅酶 Q(10)、血浆维生素 A 和 E 水平与胰岛素抵抗之间无显著相关性。我们的研究结果表明，在肥胖症中使用脂溶性营养素的脂质调整水平是必要的。此外，我们还发现肥胖人群中胰岛素抵抗与维生素 A、维生素 E 和辅酶 Q(10)水平之间无关联。
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