Mehta B C
Hematology Department, Nanavati Hospital, Mumbai, India.
Indian J Med Sci. 2004 Sep;58(9):389-93.
Iron deficiency anemia (IDA) is widely prevalent in India. IDA is preceded by a stage of latent iron deficiency (ID) where serum ferritin is reduced but hemoglobin is normal.
Present study was undertaken (1) to find prevalence of IDA and ID amongst nursing students; (2) to observe effect of hematinic therapy on Hb and red cell indices.
Nursing students were taken up for study after they gave a written consent.
Subjects were given a written questionnaire to elicit anemia related symptoms. Blood counts were done on electronic counter and serum ferritin was assayed by Elisa. Hematinic capsule was given once at bedtime for a period of three months, after which, participants again answered the same questionnaire and blood count was done.
Students' t test was used to compare the results.
There was no significant difference in Hb, MCV and MCH of normal and ID group. Differences in Hb, MCV and MCH between normal and IDA groups and between IDA and ID groups were highly significant (p < 0.001). Symptom score did not show significant difference in three groups. Ferritin levels of ID and IDA groups were significantly lower than that of normal group (p < 0.001) whereas there was no significant difference in ferritin levels of ID and IDA groups. IDA group showed highly significant improvement in Hb, MCV and MCH as a result of treatment. ID and normal groups did not show increase in Hb level after treatment but increase in MCV and MCH in both groups were highly significant.
IDA and ID were found in 20.3% and 27.5% subjects respectively. Significant rise in MCV and MCH in normal group indicated that even this apparently normal group had iron deficient erythropoiesis.
缺铁性贫血(IDA)在印度广泛流行。IDA之前存在一个潜在缺铁(ID)阶段,此时血清铁蛋白降低但血红蛋白正常。
本研究旨在(1)确定护理专业学生中IDA和ID的患病率;(2)观察补血治疗对血红蛋白(Hb)和红细胞指数的影响。
护理专业学生在签署书面同意书后被纳入研究。
向受试者发放书面问卷以了解与贫血相关的症状。使用电子计数器进行血细胞计数,并通过酶联免疫吸附测定法(ELISA)检测血清铁蛋白。每晚睡前服用一次补血胶囊,持续三个月,之后,参与者再次回答相同问卷并进行血细胞计数。
采用学生t检验比较结果。
正常组和ID组的Hb、平均红细胞体积(MCV)和平均红细胞血红蛋白含量(MCH)无显著差异。正常组与IDA组之间以及IDA组与ID组之间的Hb、MCV和MCH差异高度显著(p<0.001)。三组的症状评分无显著差异。ID组和IDA组的铁蛋白水平显著低于正常组(p<0.001),而ID组和IDA组的铁蛋白水平无显著差异。治疗后,IDA组的Hb、MCV和MCH有高度显著改善。ID组和正常组治疗后Hb水平未升高,但两组的MCV和MCH升高高度显著。
分别在20.3%和27.5%的受试者中发现了IDA和ID。正常组MCV和MCH的显著升高表明,即使是这个看似正常的组也存在缺铁性红细胞生成。