Sadeghian Mohammad Hadi, Keramati Mohammad Reza, Ayatollahi Hossein, Manavifar Lida, Enaiati Hoda, Mahmoudi Masoumeh
Indian J Hematol Blood Transfus. 2010 Jun;26(2):45-8. doi: 10.1007/s12288-010-0025-3. Epub 2010 Sep 30.
Iron deficiency is a common cause of anemia worldwide. Documentation shows that these patients have impaired immunity and are prone to infections. The aim of this study was to confirm whether serum immunoglobulins change in adult nonpregnant females with iron deficiency anemia. Based on patients' clinical history, CBC results, and serum ferritin, iron and total iron binding capacity, 45 healthy patients and 45 iron deficiency anemia (hypochrom microcytic) patients were entered into this case-control study. Serum IgG, IgA and IgM were measured in patient and control groups using the nephelometry method. Both of the groups were compared using suitable statistical test. Mean serum values of IgG, IgA and IgM in the patient group were 12.47 ± 7.67, 1.93 ± 0.92 and 1.35 ± 0.90 g/l respectively. Mean serum values for the control group were 12.51 ± 6.85, 2.14 ± 0.88 and 1.49 ± 0.73 g/l respectively. Although serum immunoglobulins were slightly lower in the patient group compared to the control group these differences were not significant with the t test. Our study showed serum immunoglobulin levels did not change in iron deficiency anemia.
缺铁是全球贫血的常见原因。文献表明，这些患者免疫力受损，容易感染。本研究的目的是确认缺铁性贫血的成年非孕女性血清免疫球蛋白是否发生变化。根据患者的临床病史、全血细胞计数结果以及血清铁蛋白、铁和总铁结合力，45名健康患者和45名缺铁性贫血（低色素小细胞性）患者进入了这项病例对照研究。采用散射比浊法测定患者组和对照组的血清IgG、IgA和IgM。使用合适的统计检验对两组进行比较。患者组IgG、IgA和IgM的血清平均值分别为12.47±7.67、1.93±0.92和1.35±0.90g/l。对照组的血清平均值分别为12.51±6.85、2.14±0.88和1.49±0.73g/l。尽管患者组的血清免疫球蛋白略低于对照组，但经t检验这些差异并不显著。我们的研究表明缺铁性贫血患者的血清免疫球蛋白水平没有变化。
