Tepper James M, Koós Tibor, Wilson Charles J
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102, USA.
Trends Neurosci. 2004 Nov;27(11):662-9. doi: 10.1016/j.tins.2004.08.007.
The vast majority of neostriatal neurons and intrinsic intrastriatal synapses are GABAergic, the latter arising from axon collaterals of spiny projection neurons and from GABAergic interneurons. An important feature of the functional organization of the neostriatum has long been assumed to be the existence of a widespread lateral inhibitory network mediated by the axon collaterals of spiny projection neurons. However, these collateral connections have recently been demonstrated electrophysiologically to be relatively weak--in contrast to feedforward interneuronal inhibition, which exerts strong effects on spike timing in spiny neurons. These new data are incompatible with current "winner-take-all" models of lateral inhibitory function in the neostriatum, and they force a modification of established concepts of the functional roles of feedback inhibition in this nucleus.
绝大多数新纹状体神经元和纹状体内的固有突触是γ-氨基丁酸能的，后者源自棘状投射神经元的轴突侧支和γ-氨基丁酸能中间神经元。长期以来，人们一直认为新纹状体功能组织的一个重要特征是存在由棘状投射神经元的轴突侧支介导的广泛的侧向抑制网络。然而，最近通过电生理学研究表明，这些侧支连接相对较弱，这与前馈性中间神经元抑制形成对比，前馈性中间神经元抑制对棘状神经元的峰电位时间有强烈影响。这些新数据与目前新纹状体侧向抑制功能的“赢家通吃”模型不相符，它们迫使人们对该核团中反馈抑制的功能作用的既定概念进行修正。
