Steinstraesser L, Oezdogan Y, Wang S C, Steinau H U
Department for Plastic Surgery, Burn Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Buerkle-de-la Camp Platz 1, 44789 Bochum, Germany.
Burns. 2004 Nov;30(7):619-27. doi: 10.1016/j.burns.2004.05.013.
Overuse of antibiotics and failure to apply basic infection control policies and procedures have contributed to the increasing multi-drug resistance of many nosocomial pathogens. The alarming increase of multi-drug-resistant bacteria (e.g. Pseudomonas aeruginosa, methicilin-resistant Staphylococci, vancomycin-resistant Enterococci) causes infected wounds associated with high mortality and morbidity in burned patients and focuses attention on the need for better treatment and prevention of wound infections. The review points out and discusses some emerging alternatives to antibiotics used in clinical practice, with special emphasis on the role of the innate immune response and potential application of human host defense peptides in thermal injury.
抗生素的过度使用以及未能实施基本的感染控制政策和程序，导致许多医院病原体的多重耐药性不断增加。多重耐药菌（如铜绿假单胞菌、耐甲氧西林葡萄球菌、耐万古霉素肠球菌）惊人的增长，致使烧伤患者出现感染伤口，伴有高死亡率和高发病率，这使人们将注意力集中在更好地治疗和预防伤口感染的必要性上。这篇综述指出并讨论了临床实践中使用的抗生素的一些新兴替代方法，特别强调了天然免疫反应的作用以及人类宿主防御肽在热损伤中的潜在应用。
