Greenfield Jerry R, Campbell Lesley V
Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney, Australia.
Clin Dermatol. 2004 Jul-Aug;22(4):289-95. doi: 10.1016/j.clindermatol.2004.01.011.
Obesity, particularly central obesity, is associated with insulin resistance. Much research has focused on mechanisms that link obesity to insulin resistance, including lipid accumulation in muscle and liver and the recently discovered adipocytokines. Insulin resistance is an important feature of a number of common conditions, including type 2 diabetes and polycystic ovary syndrome and is associated with rarer disorders, such as inherited insulin receptoropathies and genetic and acquired lipodystrophies. Despite its use for a number of years, metformin's role as an insulin sensitizer has only recently been appreciated. The discovery of a new class of insulin sensitizing agents, the thiazolidinediones, represents a major advance in the understanding of the etiology of insulin resistance, particularly in relation to adipocyte biology and possibly, its inflammatory origins.
肥胖，尤其是腹型肥胖，与胰岛素抵抗相关。许多研究聚焦于将肥胖与胰岛素抵抗联系起来的机制，包括肌肉和肝脏中的脂质蓄积以及最近发现的脂肪细胞因子。胰岛素抵抗是包括2型糖尿病和多囊卵巢综合征在内的多种常见病症的重要特征，并且与一些罕见疾病相关，如遗传性胰岛素受体病以及遗传性和获得性脂肪营养不良。尽管二甲双胍已使用多年，但其作为胰岛素增敏剂的作用直到最近才得到认识。一类新型胰岛素增敏剂噻唑烷二酮类的发现，代表了在理解胰岛素抵抗病因方面的一项重大进展，特别是在与脂肪细胞生物学以及可能的炎症起源相关方面。
