Mitzner Wayne, Wagner Elizabeth M
Department of Environmental Health Sciences, Johns Hopkins Medical Institutions, 615 North Wolfe St., Baltimore, MD 21205, USA.
J Appl Physiol (1985). 2004 Nov;97(5):1999-2004. doi: 10.1152/japplphysiol.00473.2004.
The lung is unique in its double sources of perfusion from the pulmonary and systemic circulations. One striking difference between the two circulations is the capacity for angiogenesis. The bronchial circulation has a capacity that seems quite similar to all systemic arteries, whereas the pulmonary circulation seems relatively inert in this regard. Extra-alveolar pulmonary arteries can grow somewhat in length, and septal capillaries seem to have the capability of reforming, but these processes do not seem to occur with nearly the same intensity associated with the bronchial arteries. In this review, we emphasize these differences between the two circulations of the lung, anticipating that future research will allow more focused probing into the molecular signaling that regulates the novel mechanistic and pathological pathways of each.
肺的独特之处在于其同时接受来自肺循环和体循环的双重灌注。这两种循环之间一个显著的差异在于血管生成的能力。支气管循环的能力似乎与所有体循环动脉相当，而肺循环在这方面似乎相对不活跃。肺泡外肺动脉在长度上可以有所增长，间隔毛细血管似乎具有重新形成的能力，但这些过程发生的强度似乎远不及支气管动脉。在本综述中，我们强调肺的这两种循环之间的差异，预计未来的研究将使我们能够更有针对性地探究调节每种循环独特机制和病理途径的分子信号。
