Corver Karen, Kerkhof Marjan, Brussee Jessica E, Brunekreef Bert, van Strien Rob T, Vos Ada P, Smit Henriette A, Gerritsen Jorrit, Neijens Herman J, de Jongste Johan C
Department of Pediatrics, Division of Respiratory Medicine, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.
Pediatr Allergy Immunol. 2006 Aug;17(5):329-36. doi: 10.1111/j.1399-3038.2006.00410.x.
Exposure to high allergen levels in early life is a risk factor for the development of allergy. We previously reported limited effects of mite allergen impermeable mattress covers in the prevention and incidence of asthma and mite allergy (PIAMA) cohort at the age of 1 and 2 yr. We now present the results of follow-up at 4 yr objectives. To examine the effects of early reduction of house dust mite (HDM) allergen exposure by means of mattress covers on the incidence of allergy and asthma symptoms in the PIAMA birth cohort at the age of 4 yr. High-risk children (allergic mother) were prenatally recruited and randomly allocated to three groups; receiving mite allergen impermeable mattress covers (n = 416), placebo covers (n = 394) or no intervention (n = 472). At 4 yr of age, atopy was assessed by questionnaire; specific Immunoglobulin E (IgE) to inhalant and food allergens was measured in serum. Dust samples collected from the children's mattresses were analysed for mite allergens. Dermatophagoides farinae1 allergen (Der f 1) levels in dust were reduced in the active group. However, Dermatophagoides pteronissinus 1 (Der p 1) levels, sensitization and atopic symptoms were similar in all groups. We found no effect of mite allergen impermeable mattress covers on sensitization and atopy at 4 yr. Moreover, the allergen reducing effects of the covers had disappeared for one of the two mite allergens that were measured.
早年暴露于高过敏原水平是过敏发生的一个风险因素。我们之前报道了在哮喘和螨过敏预防与发病率队列研究（PIAMA）中，螨过敏原不可渗透床垫罩在1岁和2岁时的效果有限。我们现在展示4岁时的随访结果。目的是研究通过床垫罩在生命早期减少屋尘螨（HDM）过敏原暴露对PIAMA出生队列4岁时过敏和哮喘症状发病率的影响。高危儿童（母亲过敏）在产前被招募并随机分为三组；分别使用螨过敏原不可渗透床垫罩（n = 416）、安慰剂床垫罩（n = 394）或不进行干预（n = 472）。在4岁时，通过问卷调查评估特应性；测定血清中针对吸入性和食物过敏原的特异性免疫球蛋白E（IgE）。对从儿童床垫收集的灰尘样本进行螨过敏原分析。活性组灰尘中的粉尘螨1过敏原（Der f 1）水平降低。然而，所有组中的热带无爪螨1（Der p 1）水平、致敏情况和特应性症状相似。我们发现在4岁时，螨过敏原不可渗透床垫罩对致敏和特应性没有影响。此外，所测量的两种螨过敏原之一的床垫罩的过敏原减少效果已经消失。
