Uchida Sunao, Maehara Taketoshi, Hirai Nobuhide, Kawai Kensuke, Shimizu Hiroyuki
Department of Sleep Disorders Research, Tokyo Institute of Psychiatry, 156-8585 Tokyo, Japan.
J Clin Neurosci. 2003 May;10(3):371-4. doi: 10.1016/s0967-5868(03)00025-0.
In previous studies we observed gamma (30-150 Hz) and beta-1 (10-20 Hz) oscillations in the medial temporal lobe (MTL) using subdural electrodes. The beta-1 was present during wake and REM sleep while gamma was present in all states. Recently we studied a patient (35 years M) with electrodes attached to the anterior cingulate cortex (ACC). This structure showed regular theta (5-6 Hz) oscillations. In the first recording, electrodes were attached to the MTL, that demonstrated the beta-1 and gamma oscillations. Two months later, electrodes were placed on orbitofrontal and ACC and an all night sleep recording was carried out. The ACC exhibited a highly regular and continuous theta oscillation during wakefulness and REM sleep, but not during NREM sleep. Since this same subject showed beta-1 oscillations in the MTL, it is probable that the theta in the ACC is independent of beta-1 in the MTL. This single case suggests the existence of two different frequency oscillators in the human limbic system. Elucidating their functional roles will be an interesting challenge for future studies.
在之前的研究中，我们使用硬膜下电极在内侧颞叶（MTL）观察到了γ（30 - 150赫兹）和β-1（10 - 20赫兹）振荡。β-1出现在清醒和快速眼动睡眠期间，而γ在所有状态下都存在。最近，我们研究了一名35岁男性患者，其电极连接在前扣带回皮质（ACC）。该结构显示出规则的θ（5 - 6赫兹）振荡。在首次记录中，电极连接在MTL上，显示出β-1和γ振荡。两个月后，电极放置在眶额皮质和ACC上，并进行了整夜睡眠记录。ACC在清醒和快速眼动睡眠期间表现出高度规则且持续的θ振荡，但在非快速眼动睡眠期间则没有。由于同一受试者在MTL中显示出β-1振荡，ACC中的θ振荡很可能独立于MTL中的β-1。这一单个病例表明人类边缘系统中存在两种不同频率的振荡器。阐明它们的功能作用将是未来研究的一个有趣挑战。
