Fraunfelder Frederick W
Casey Eye Institute, Oregon Health and Science University, Portland 97239-4197, USA.
Am J Ophthalmol. 2004 Oct;138(4):639-47. doi: 10.1016/j.ajo.2004.04.072.
To review the more significant herbal and nutritional agents of clinical importance to ophthalmologists and describe the ocular side effects for each. World Health Organization (WHO) classification and guidelines for clinicians are provided.
Retrospective observational case series.
A retrospective observational case series of reports of ocular side effects or systemic side effects from medications used for the eye from herbal medicines and nutritional supplements. Cases were collected from spontaneous reports submitted to the WHO, the Food and Drug Administration, and the National Registry of Drug-Induced Ocular Side Effects. A review of the world's literature was performed to obtain additional case reports and insight into adverse ocular reactions. Data were collected on age, gender, duration of therapy, concomitant medications, dosage, and dechallenge and rechallenge results.
The National Registry of Drug-Induced Ocular Side Effects received 263 spontaneous reports, in addition to 60 case reports from the literature. Canthaxanthine, chamomile, Datura, Echinacea purpurea, Ginkgo biloba, licorice, niacin, and vitamin A are all associated with clinically significant ocular side effects.
Herbal medicines and nutritional supplements can cause ocular side effects. Clinicians need to recognize these adverse events, because a large segment of the population uses them, many times without the treating physician's knowledge.
回顾对眼科医生具有临床重要性的更显著的草药和营养制剂，并描述每种制剂的眼部副作用。提供了世界卫生组织（WHO）的分类和针对临床医生的指南。
回顾性观察病例系列。
对来自草药和营养补充剂的用于眼部的药物的眼部副作用或全身副作用报告进行回顾性观察病例系列研究。病例收集自提交给WHO、美国食品药品监督管理局以及药物性眼部副作用国家登记处的自发报告。对全球文献进行综述以获取更多病例报告并深入了解眼部不良反应。收集了关于年龄、性别、治疗持续时间、伴随用药、剂量以及撤药和再用药结果的数据。
除了文献中的60例病例报告外，药物性眼部副作用国家登记处收到了263份自发报告。角黄素、洋甘菊、曼陀罗、紫锥菊、银杏、甘草、烟酸和维生素A均与具有临床意义的眼部副作用相关。
草药和营养补充剂可引起眼部副作用。临床医生需要认识到这些不良事件，因为很大一部分人群使用它们，而且很多时候治疗医生并不知情。
