内皮祖细胞在肿瘤血管生成中的作用。
The involvement of endothelial progenitor cells in tumor angiogenesis.
作者信息
Ribatti Domenico
机构信息
Department of Human Anatomy and Histology, University of Bari Medical School, Bari I-70124, Italy.
出版信息
J Cell Mol Med. 2004 Jul-Sep;8(3):294-300. doi: 10.1111/j.1582-4934.2004.tb00319.x.
Abstract
Endothelial progenitor cells (EPCs) have been isolated from peripheral blood CD34, VEGFR-2, or AC 133 (CD133) antigen-positive cells, which may home to site of neovascularization and differentiate into endothelial cells in situ. Endothelial cells contribute to tumor angiogenesis, and can originate from sprouting or co-option of neighbouring pre-existing vessels. Emerging evidence indicate that bone marrow-derived circulating EPCs can contribute to tumor angiogenesis and growth of certain tumors. This review article will summarize the literature data concerning this new role played by EPCs in tumor angiogenesis.
摘要
内皮祖细胞（EPCs）已从外周血CD34、血管内皮生长因子受体-2（VEGFR-2）或AC133（CD133）抗原阳性细胞中分离出来，这些细胞可能归巢至新生血管形成部位并原位分化为内皮细胞。内皮细胞促进肿瘤血管生成，可起源于邻近已有血管的出芽或套叠。新出现的证据表明，骨髓来源的循环EPCs可促进某些肿瘤的血管生成和生长。本文将综述有关EPCs在肿瘤血管生成中这一新作用的文献数据。
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