大肠杆菌的耐酸性：一个嗜酸“业余者”的故事
Escherichia coli acid resistance: tales of an amateur acidophile.
作者信息
Foster John W
机构信息
Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, Alabama 36695, USA.
出版信息
Nat Rev Microbiol. 2004 Nov;2(11):898-907. doi: 10.1038/nrmicro1021.
Gastrointestinal pathogens are faced with an extremely acidic environment. Within moments, a pathogen such as Escherichia coli O157:H7 can move from the nurturing pH 7 environment of a hamburger to the harsh pH 2 milieu of the stomach. Surprisingly, certain microorganisms that grow at neutral pH have elegantly regulated systems that enable survival during excursions into acidic environments. The best-characterized acid-resistance system is found in E. coli.
胃肠道病原体面临着极端酸性的环境。在片刻之间，诸如大肠杆菌O157:H7这样的病原体就能从pH值为7的汉堡包的滋养环境转移到pH值为2的胃部恶劣环境中。令人惊讶的是，某些在中性pH值下生长的微生物拥有精心调节的系统，使其能够在进入酸性环境时存活下来。最具特征的抗酸系统存在于大肠杆菌中。
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