Zeidan Zeidan A, Sultan Intisar E, Guraya Shaista S, Al-Zalabani Abdulmohsen H, Khoshhal Khalid I
Department of Family and Community Medicine, College of Medicine, Taibah University, Al Madinah Al Munawwarah, Kingdom of Saudi Arabia. E-mail.
Saudi Med J. 2016 Nov;37(11):1225-1233. doi: 10.15537/smj.2016.11.16248.
To screen for low bone mineral density among young adult Saudi women using quantitative ultrasound (QUS) and exploring the high risk groups. Methods: A cross-sectional study was performed on 279, 20-36 years old female students and employees of Taibah University, Al Madinah Al Munawwarah, Kingdom of Saudi Arabia between January and May 2014. The study included bone status assessed using QUS, a structured self-reported questionnaire, anthropometric measurements, and evaluation of bone markers of bone metabolism. Results: The prevalence of low bone mineral density was 9%. Serum osteocalcin was found significantly higher in candidates with low bone mineral density, 20.67 ng/ml versus 10.7 ng/ml, and it was negatively correlated with T-scores. At any given point in time the exposed subjects to low calcium intake and inadequate sun exposure in the population were 11 times and 3 times more likely to have low bone mineral density, (adjusted odds ratio [OR], 11.0; 95%confidence interval [CI]=3.16, 38.34; p=0.001) and (adjusted OR, 3.32, 95%CI=1.27, 8.66, p less than 0.01). Conclusion: Early detection screening programs for low bone mineral density are needed in Saudi Arabia as it affects young Saudi women specially the high-risk group that includes young women with insufficient calcium intake and insufficient sun exposure. Serum osteocalcin as a biomarker for screening for low bone mineral density could be introduced.
使用定量超声（QUS）筛查沙特年轻成年女性中的低骨密度，并探索高危人群。方法：2014年1月至5月，对沙特阿拉伯麦地那穆纳瓦拉市泰巴大学的279名20 - 36岁的女学生和女员工进行了一项横断面研究。该研究包括使用QUS评估骨状态、一份结构化的自我报告问卷、人体测量以及骨代谢骨标志物的评估。结果：低骨密度的患病率为9%。发现骨密度低的受试者血清骨钙素显著更高，分别为20.67 ng/ml和10.7 ng/ml，且与T值呈负相关。在任何给定时间点，人群中钙摄入量低和日照不足的受试者发生低骨密度的可能性分别高出11倍和3倍，（调整后的优势比[OR]，11.0；95%置信区间[CI]=3.16, 38.34；p = 0.001）和（调整后的OR，3.32，95%CI = 1.27, 8.66，p小于0.01）。结论：沙特阿拉伯需要开展低骨密度早期检测筛查项目，因为它影响沙特年轻女性，特别是包括钙摄入不足和日照不足的年轻女性在内的高危人群。血清骨钙素可作为筛查低骨密度的生物标志物引入。
