Ansari Asad, Li Shaobing, Abzug Mark J, Weinberg Adriana
University of Colorado School of Medicine, Denver, Colorado 90262, USA.
Emerg Infect Dis. 2004 Aug;10(8):1450-4. doi: 10.3201/eid1008.030788.
The role and frequency of human herpesviruses (HHV)-6 and -7 in central nervous system (CNS) diseases of children are unclear. Cerebrospinal fluid samples from 245 pediatric patients (median age 43 days), submitted for evaluations of possible sepsis or of neurologic symptoms, were tested for HHV-6 and HHV-7 DNA by polymerase chain reaction. HHV-6 DNA was found in 3 of 245 samples, and HHV-7 was found in 0 of 245 samples. The three patients with HHV-6 DNA were <2 months of age. HHV-6 was likely pathogenic in two patients with meningitis who lacked evidence of another microbiologic cause. HHV-6 and HHV-7 are uncommon causes of CNS infection in children. HHV-6 may occasionally cause meningitis in young infants.
人类疱疹病毒(HHV)-6和-7在儿童中枢神经系统(CNS)疾病中的作用及感染频率尚不清楚。对245名儿科患者(中位年龄43天)的脑脊液样本进行检测,这些样本因可能患有败血症或神经系统症状而送检,采用聚合酶链反应检测HHV-6和HHV-7 DNA。245份样本中,3份检测出HHV-6 DNA,245份样本中未检测出HHV-7。3例检测出HHV-6 DNA的患者年龄均小于2个月。在2例缺乏其他微生物病因证据的脑膜炎患者中,HHV-6可能具有致病性。HHV-6和HHV-7是儿童中枢神经系统感染的罕见病因。HHV-6偶尔可能导致幼儿患脑膜炎。