患有神经体征和症状的患者中，人疱疹病毒6型和人疱疹病毒7型对中枢神经系统的侵袭。
Invasion by human herpesvirus 6 and human herpesvirus 7 of the central nervous system in patients with neurological signs and symptoms.
作者信息
Yoshikawa T, Ihira M, Suzuki K, Suga S, Matsubara T, Furukawa S, Asano Y
机构信息
Department of Pediatrics, Fujita Health University School of Medicine, Aichi, Japan.
出版信息
Arch Dis Child. 2000 Aug;83(2):170-1. doi: 10.1136/adc.83.2.170.
Abstract
METHODS
A total of 43 children with neurological signs and symptoms were enrolled in the study. All children were suspected of having meningitis, and lumbar punctures were performed. Human herpesvirus 6 (HHV-6) and HHV-7 DNA was detected in cerebrospinal fluid (CSF) and peripheral blood mononuclear cells (PBMC) by nested polymerase chain reaction.
RESULTS
Most patients had detectable serum antibody to both HHV6 and 7. HHV6 DNA was detected in PBMC of 15 patients and in CSF cell pellet of seven. Corresponding figures for HHV7 were 28 and 6.2/7, and 5/6 with CSF viral DNA also had it in PBMC, respectively. No viral DNA was detected in CSF supernatants. The seven HHV6 CSF viruses were all variant B.
CONCLUSION
These data suggest that HHV-7 may invade the CNS.
摘要
方法
共有43名有神经症状和体征的儿童纳入本研究。所有儿童均怀疑患有脑膜炎，并进行了腰椎穿刺。通过巢式聚合酶链反应在脑脊液（CSF）和外周血单核细胞（PBMC）中检测人疱疹病毒6（HHV-6）和HHV-7 DNA。
结果
大多数患者可检测到针对HHV6和7的血清抗体。在15例患者的PBMC和7例患者的CSF细胞沉淀中检测到HHV6 DNA。HHV7相应的数据分别为28例和6.2/7例，并且在CSF中检测到病毒DNA的5/6例患者其PBMC中也检测到病毒DNA。在CSF上清液中未检测到病毒DNA。7例CSF中的HHV6病毒均为B型变体。
结论
这些数据表明HHV-7可能侵袭中枢神经系统。
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