Cabré E, Periago J L, Mingorance M D, Fernández-Bañares F, Abad A, Esteve M, Gil A, Lachica M, González-Huix F, Gassull M A
Department of Gastroenterology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
Am J Clin Nutr. 1992 Apr;55(4):831-7. doi: 10.1093/ajcn/55.4.831.
The plasma lipid fatty acid (FA) profile was measured in 83 healthy subjects (35 men, 48 women; ages 18-82 y). The association of 19 variables (including serum antioxidant micronutrients) with saturated (SFA), monounsaturated (MUFA), essential (EFA), and polyunsaturated fatty acid (PUFA) status was assessed by stepwise multiple-linear regression. Serum selenium was directly associated with percent EFA and n-6 PUFA (r = 0.38, P = 0.0004 for both) and inversely related to percent SFA in phospholipids (r = -0.38, P = 0.0004). Serum selenium was the only predictor of the unsaturation index of this fraction (r = 0.45, P = 0.0000). Although associations of plasma FA pattern with age, serum cholesterol, bilirubin, vitamin E, and zinc were also disclosed, only for selenium did the antioxidant effect seem to explain this relationship. These results suggest that antioxidant micronutrients should be measured when PUFA metabolism is studied. The relationship between plasma FA and antioxidant micronutrients in disease states needs further research.
对83名健康受试者（35名男性，48名女性；年龄18 - 82岁）的血浆脂质脂肪酸（FA）谱进行了测量。通过逐步多元线性回归评估了19个变量（包括血清抗氧化微量营养素）与饱和脂肪酸（SFA）、单不饱和脂肪酸（MUFA）、必需脂肪酸（EFA）和多不饱和脂肪酸（PUFA）状态之间的关联。血清硒与EFA百分比和n - 6多不饱和脂肪酸直接相关（两者r = 0.38，P = 0.0004），与磷脂中SFA百分比呈负相关（r = -0.38，P = 0.0004）。血清硒是该部分不饱和指数的唯一预测因子（r = 0.45，P = 0.0000）。尽管也揭示了血浆FA模式与年龄、血清胆固醇、胆红素、维生素E和锌之间的关联，但似乎只有硒的抗氧化作用能解释这种关系。这些结果表明，在研究多不饱和脂肪酸代谢时应测量抗氧化微量营养素。疾病状态下血浆脂肪酸与抗氧化微量营养素之间的关系需要进一步研究。
