Mohorovic Lucijan
Obstetric and Gynecologic Primary Care, Labin, Rabac 52221, Croatia.
Early Hum Dev. 2004 Nov;80(2):115-23. doi: 10.1016/j.earlhumdev.2004.06.001.
The objective of this study was to define the most critical gestation period for adverse effects of environmental toxics in terms of preterm delivery (<37 weeks) and low birthweight (<2500 g) in humans.
From January 1, 1987 to December 31, 1989, 704 women were included in a retrospective epidemiological study. All were from the district of Labin and lived in the vicinity of a coal power plant Plomin 1, Croatia. This plant is the single large source of air pollution in the area. The coal used for fuel is extremely rich with sulfur, 9-11%. Daily, weekly, and monthly consumption of coal and related SO2 emissions were calculated for each pregnant woman from the beginning to the end of pregnancy.
We found that a greater and longer exposure to SO2 emissions during the initial two months of pregnancy resulted in a significantly shorter gestation (end of the first month: -0.0914, p=0.008, end of the second month: -0.0806, p=0.016) and in lower body mass of a newborn (end of the first month: -0.0807, p=0.016, end of the second month -0.0733, p=0.026).
The results of this study confirm the role of inhaled environmental toxics in the early development of human embryo and in adverse pregnancy course caused by permanent oxidative stress, misbalanced production of reactive oxygen species (ROS), reactive nitrogen species (RNS), reactive sulfur species (RSS), and other unfavorable metabolic processes on early embryogenesis, resulting in growth-arrested cells.
本研究的目的是就人类早产（<37周）和低出生体重（<2500克）确定环境毒素产生不良影响的最关键妊娠期。
从1987年1月1日至1989年12月31日，704名女性被纳入一项回顾性流行病学研究。所有女性均来自拉宾地区，居住在克罗地亚普洛明1号燃煤发电厂附近。该工厂是该地区唯一的大型空气污染源。用于燃料的煤含硫量极高，为9 - 11%。计算了每名孕妇从怀孕开始到结束时的每日、每周和每月煤炭消耗量及相关二氧化硫排放量。
我们发现，孕期最初两个月接触二氧化硫排放的量越大、时间越长，妊娠期显著缩短（第一个月末：-0.0914，p = 0.008，第二个月末：-0.0806，p = 0.016），新生儿体重越低（第一个月末：-0.0807，p = 0.016，第二个月末：-0.0733，p = 0.026）。
本研究结果证实了吸入的环境毒素在人类胚胎早期发育以及由永久性氧化应激、活性氧（ROS）、活性氮（RNS）、活性硫（RSS）产生失衡和其他不利于早期胚胎发生的代谢过程导致的不良妊娠过程中的作用，这些过程会导致细胞生长停滞。
