Scarlett J D, Read H, O'Dea K
Department of Haematology, Geelong Hospital, Victoria, Australia.
Am J Hematol. 1992 Feb;39(2):79-83. doi: 10.1002/ajh.2830390202.
A modified protein-bound cobalamin absorption test was used to study dietary cobalamin absorption in healthy adults of different age groups and patients with isolated low serum concentrations of cobalamin. Dietary cobalamin absorption was significantly reduced in healthy adults aged 55-75 years compared with young adults, with a further reduction in those older than 75 years. No difference was detected between dietary cobalamin absorption in patients with isolated low serum cobalamin and controls of a similar age group. Cobalamin malabsorption was associated with elevated serum gastrin. The diagnostic value of this protein-bound cobalamin absorption test in the elderly was limited by the frequent finding of reduced absorption in healthy elderly people with normal serum cobalamin concentrations. The performance of such tests should be evaluated in different age groups before application in diagnosis.
采用改良的蛋白结合钴胺素吸收试验，研究不同年龄组健康成年人及血清钴胺素浓度单独降低的患者对膳食钴胺素的吸收情况。与年轻成年人相比，55至75岁的健康成年人膳食钴胺素吸收显著降低，75岁以上者吸收进一步降低。血清钴胺素单独降低的患者与相似年龄组对照的膳食钴胺素吸收之间未检测到差异。钴胺素吸收不良与血清胃泌素升高有关。这种蛋白结合钴胺素吸收试验在老年人中的诊断价值受到限制，因为经常发现血清钴胺素浓度正常的健康老年人吸收降低。在应用于诊断之前，应在不同年龄组评估此类试验的性能。
