老年人中钴胺素的吸收：健康受试者和血清钴胺素浓度低的受试者的结果。

Cyanocobalamin absorption in the elderly: results for healthy subjects and for subjects with low serum cobalamin concentration.

作者信息

Nilsson-Ehle H, Jagenburg R, Landahl S, Lindstedt G, Swolin B, Westin J

出版信息

Clin Chem. 1986 Jul;32(7):1368-71.

PMID:3719947

Abstract

We examined the intestinal absorption of cyano[57Co]cobalamin from a non-protein-bound test dose given to 38 subjects from a population of elderly. The subjects were 76 years old and were apparently free from conditions known to affect cyanocobalamin absorption. Their gastric mucosal function was normal, as judged from determinations of serum gastrin and pepsinogen I. The urinary excretion of radioactivity during the first 24 h was 24(SD 7)%, range 8.6 to 45.2%, corresponding to a health-associated reference interval of 10 to 38%. The results indicate that cyanocobalamin absorption does not decline during normal aging. Duplicate studies were performed in another 20 subjects (70-81 years old) from the same population study; these subjects had a serum cobalamin concentration less than 130 pmol/L. The imprecision (CV) was 23%.

摘要

我们研究了从非蛋白结合测试剂量给予一组老年人群中38名受试者的氰钴胺素[57Co]的肠道吸收情况。受试者年龄为76岁，显然没有已知会影响氰钴胺素吸收的疾病。根据血清胃泌素和胃蛋白酶原I的测定判断，他们的胃黏膜功能正常。前24小时内放射性物质的尿排泄量为24%（标准差7%），范围为8.6%至45.2%，对应于与健康相关的参考区间10%至38%。结果表明，在正常衰老过程中氰钴胺素吸收不会下降。对同一人群研究中的另外20名受试者（70 - 81岁）进行了重复研究；这些受试者的血清钴胺素浓度低于130 pmol/L。不精密度（CV）为23%。